To answer NO I do not believe so at least not close as in 3 or 4 generations. Pioneer Families of Missouri reports on Hiram Marcellus Threlkeld and wife Nancy nee Craig coming to Callaway County from Scott Co., KY. William F Threlkeld, our interest, is their son. His brother John Leland stuck in Callaway county. I should point out that it appears Threlkeld is the preferred spelling. Hiram has a number of land grants going back to 1836 in Callaway county.