James Hamilton Jr should be identified as Governor of South Carolina and one of the main leaders of the Nullification movement. Since no direct Federal tax existed, the tarrif and other levies diminished the incomes of men like Hamilton and his patrons, the wealthiest Southern planters and their patrons. The tariff also damaged New England shipping interests as smaller, less valuable cargoes came into American ports. The tariff had no financial impact on subsistence farmers (North and South) and other citizens who did not purchase overseas imports. The tariff was designed to improve business for American manufacturers and their employees by making their products more competitive.

http://docsouth.unc.edu/church/hamilton/bio.html
http://www.sciway.net/hist/governors/jhamilton.html

Aside from higher tax rates for planters, James Hamilton's letter to Governor Jame Floyd of Virginia outlines other grievances. He states that Yankees sought to provoke discontent among the slaves by introducing Christian teachings. As a leading actor in supression of the Denmark Vessey Rebellion of 1822, Hamilton had a strong interest in this issue.
http://memory.loc.gov/cgi-bin/ampage?collId=mssmisc&fileName=ody/ody0107/ody0107page.db&recNum=0&itemLink=/ammem/aaohtml/exhibit/aopart1.html@0107&linkText=9

As discussed several months ago, the tariff diminished as a sectional issue after the Nullification controversy. Political leaders from the South who opposed high tariff rates helped to draft the Walker Tariff of 1846, which established low rates for the next fourteen years.
http://millercenter.org/president/polk/essays/biography/4