Wittsburg was located in St. Francis County, Arkansas, until Cross County was created in 1862. The community is now in central Cross County, near the St. Francis River, on Hwy. 163, about two or three miles south of Levesque and about four or five miles southeast of Wynne.

Wittsburg and Jacksonport were the two parole centers for the Confederate troops in northeast Arkansas. Paroles at Wittsburg were signed on May 25, 1865; paroles at Jacksonport were signed on June 5, 1865.