Isom Edwards also served briefly in Co. F, 15th Northwest Arkansas Infantry, in 1862. He enlisted at Camp Boston Mountain, Arkansas, on February 10, 1862, for twelve months; and was discharged as a "non-conscript" at Camp Priceville, Tupelo, Mississippi, on July 16, 1862, due to being over the maximum age under the Conscript Act. When discharged, he was reported as a farmer, age 38, born in North Carolina, a resident of Benton County, Arkansas. His name was erroneously entered on the rolls as Isham Edwards. (The names Isom and Isham were frequently intermixed in Confederate service records. When trying to identify a soldier, it helps to do a search using both names. Ditto with Josiah and Joshua, Edward and Edmund, etc.)

Later, he purportedly enlisted in Co. B, 2nd Cherokee Mounted Volunteers. His widow, Mrs. Nancy Edwards, applied for a Confederate pension from Benton County in 1910, citing her late husband's service in the 2nd "Arkansas" Cherokee Cavalry, and stated that he had died on September 8, 1906. Her pension application was approved on August 2, 1910 (Pension File No. 14772).