Here are two possible locations. Note, they were located nearby the Mill Creek PO.

On December 21, a company of Reeves’ cavalry under Captain David Reed captured Centerville and about 100 Union soldiers with their horses. Leaving a small garrison behind, Reed returned to Ripley County to turn the prisoners over the Colonel Reeves who had been recruiting soldiers in the area and was camped at Pulliam’s farm 14 miles southwest of Doniphan. Word of the Centerville raid quickly reached Pilot Knob and two mounted cavalry companies under Major Wilson were sent in hot pursuit of Reed.
http://doniphanmissouri.org/yahoo_site_admin/assets/docs/Civil_War_Days_historical_handout_2010_secondWHOLE100192055.15180758.pdf

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Skirmish at Pulliam Farm
https://sites.google.com/site/rcmacw/pulliam-springs-incident

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1860 Federal Census
NAME: Louisa Little
AGE IN 1860: 26
BIRTH YEAR: abt 1834
BIRTHPLACE: Missouri
HOME IN 1860: Union Township, Ripley, Missouri
GENDER: Female
POST OFFICE: Mill Creek

HOUSEHOLD MEMBERS:
NAME AGE
Hardy Little 27 Farmer
Louisa Little 26
Lucinda Little 5
Moses Little 3
M Little 1