No, Sally, I don't see any fight or secession (regardless of its legality or illegality) being necessary.
I think this long-term transfer of rights will be nearly voluntary and simply happen by default since the central government will have demonstrated over and over again their inability to manage such huge, complex problems.
By then it will have become apparent that the only political jurisdiction capable of handling such problems will be the state, not the central government.
That, in turn, will lead to different implementations of different solutions to identical problems across all states with private enterprise subsequently stepping in to try to introduce "standard" solutions to such problems within each state.
Potentially the biggest problem will be the massive redistribution of revenues from the central government back to state governments to support these huge programs that the Feds will, by then, willingly admit they are unable to handle.
Remember, one of those huge problems will be public education. What I am talking about is the dissolution of the Education component of Health, Education and Welfare with Education also being returned to the state. That's when each state might start retooling its curriculums (history and otherwise) to include truth in the teaching of history.
I will guess and that is all it is, that the quality of life of individuals like us will be markedly improved in proportion to the extent to which the central government is down-sized by the forces I see at work right now.
I also doubt that I will see the fruits of all this in my lifetime, but some of us may.