I've not hunted along these lines before but remember that "Sikeston" MO was founded by John Sikes of New Madrid County about 1860 or so. He established a burg on the El Camino Real of Spainish land grant fame which became US 61 between New Orleans and St. Louis. There were several Sikes families in the bootheel at the beginning of the war. I'll hunt around and see what comes up.

John R.